Forum Replies Created
June 24, 2022 at 1:51 am #211566
Or an individual who puts country above party. What we used to call a patriot, and in this instance a person that is not a seditious weasel. She is a true conservative.October 20, 2021 at 11:08 pm #197351
stupid is as stupid does….May 19, 2021 at 12:09 am #188816
I am not a layman, this is my bread and butter.
First I commend Dr. Ketchum’s courage for taking on the study in the first place. But there are many many issues with her study, and how she has dealt with its publication is really suspect.
She is the first and communicating author of this study (that means she is the person who conducted the work, oversaw the study, and is responsible for preparing the manuscript). She initially submitted it to Nature, a prestigious journal with very high standards. When the editors rejected it, she submitted it to PLOS One. They declined to send it out for review.
Multiple rounds of rejection, followed by revision and resubmission is generally the norm when preparing scientific evidence for publication. It is not uncommon for a manuscript to be shopped around to a large number of journals before finding a publisher. Through this painful process of multiple rounds of peer review, issues like those identified by John can be discussed and addressed. The resulting modifications to the manuscript that occur help enhance the overall quality and strength of the study. This is peer review. It is hard. It can be painful. It can take a lot of time.
Instead of fighting to get her work published, she chose to self publish. As a result, the three complete genomes she claims to have generated will never be available for further study. It is now impossible for people to repeat her results or to build upon her work.
Perhaps part of the confusion results from her lack of experience with the process of scientific publication. As per her suggestion, I did look up her CV. Most of the “publications” listed in her CV represent meeting abstracts. I could identify only four or five journal publications. She was the first and communicating author on only two of these:
Ketchum, M. S. (1996) Neonatal Isoerythrolysis: Is Your Foal at Risk? Voice of the Tennessee Walking Horse. August, 1996:154-155
Ketchum, M. S. (1997) It’s in the Blood, Understanding Genetic Testing for Homozygous Tobiano Coloration Paint Horse Journal, April 1997:134-138
I am sorry, but there is no need for some deep government conspiracy to suppress the publication of her data – she has done that herself.April 15, 2021 at 12:46 am #186569
Wolf, I just don’t have time to deal with your issues. I can quickly address one of the things you are confused about. PCR. I have used it for over 30. It works. And no, its “inventor” Kery Mullis did not criticize its use for Covid detection. This was just made up by one of your “experts”. Dr. Mullis died in August 2019.April 14, 2021 at 9:15 am #186459
Sorry, I just do not spend much time or energy with this stuff… I just don’t have the time or energy to deal with it. I invoke Brandolini’s law (Google it).
But in good faith, I will try to deal with some of the major issues identified.
Do I trust big Pharma? Of course not. They are in business to make money and their feet should be held to fire. Do I wish that more time had been spent on clinical trials? Of course.
What about the VAERS Data? their disclaimer reads: “VAERS accepts reports of adverse events and reactions that occur following vaccination. Healthcare providers, vaccine manufacturers, and the public can submit reports to the system. While very important in monitoring vaccine safety, VAERS reports alone cannot be used to determine if a vaccine caused or contributed to an adverse event or illness. The reports may contain information that is incomplete, inaccurate, coincidental, or unverifiable. In large part, reports to VAERS are voluntary, which means they are subject to biases. This creates specific limitations on how the data can be used scientifically. Data from VAERS reports should always be interpreted with these limitations in mind.” At present we are looking at hundreds of millions of Covid vaccine doses administered around the globe. PreCovid people also got sick and died. When you preferentially vaccinate people in their 80’s and 90’s, some of them are just going to get sick and die. Is this from the vaccine, or is it from being 80-90 years old? Based on the numbers I have seen, and trust, it does not appear to me that side effects are underreported.
Do the vaccines protect from infection? Yes and no. No vaccine is 100% effective. What they can do is significantly limit infection and prevent the worst of Covid symptoms. Have the death numbers been artificially inflated – REALLY? OVER THE ENTIRE PLANET? THEY ARE JUST FAKING ALL THE DEAD PEOPLE? SWEET GOD IN HEAVEN! Is Tony Fauci some kind of boogeyman? No. This is just residue from the crap thrown at him because he was not a good player (read liar) on team Trump, and this junk is now just being echoed throughout the nutosphere. Are there side effects of the current vaccines? Yes, many people experience nasty flu like symptoms. Have the side effects been under reported? Not that I have seen. Flu symptoms suck! A lot of people get them. I am also aware of the recent potential problems surrounding the astrazeneca/Johnson and Johnson vaccines. Both these vaccines use an adenoviral vector to express the Covid coat protein as a vaccine. The potential complications described can be life threatening. But – the same disease was present before Covid. It is a well-documented, but quite rare clotting disorder seen in approximately 12 out of a million people in the general population per year. The potential vaccine effect has been suggested to occur in about 1 out of a million vaccinated people. So, related to the vaccine or not? It was appropriate to pause vaccination with these agents until the issue can be clarified/addressed. Importantly, this atypical clotting problem is also very treatable when caught early!
Is Covid real and dangerous? Big time! I see the damage every day. I believe that I have a reasonably good grasp of the general topic as it relates to the associated risks of Covid infection, and the issues surrounding the vaccine biology. My Ph.D. is in biochemistry and molecular immunology. I have over five years of postdoctoral training in molecular and cellular immunology at US and European universities. I have a second doctorate in immunology (German habilitation – a certification not available in the US) that is a step beyond a Ph.D. or M.D. I have authored over 200 peer-reviewed scientific papers, reviews and book chapters, a large portion of which have dealt with the role of immunity in disease. I am a Professor of Medicine and teach immunology and molecular medicine at a major European university. I am board certified in immunology and work as an immunology editor for scientific journals. The large university clinic where I work deals with some of the most difficult cases.
That said, I most certainly do not have all of the answers, but what I can say is that I am genuinely terrified by what this virus can do to the human body. Not only in the short term, but also by way of the potentially permanent damage it can inflict on the body. I am very familiar with the pathophysiology at play, and I understand what it can mean for millions upon millions of people down the road. Psychological impairment, more chronic heart disease, more chronic kidney disease, more chronic lung disease..… limited options for therapy….
What about the other vaccines? Are they safe? Everyone has to weigh the risks and benefits and decide for themselves. From my perspective, I very much look forward to getting my second jab next week, and I am very happy that most of my family has now been fully vaccinated.
Stay safe!April 13, 2021 at 3:52 am #186321
Well, she is certainly full of something…..April 12, 2021 at 6:11 am #186236
Knobby, I believe that I do have an understanding of how mRNA vaccines work.
mRNAs are transient signals produced by all cells. They represent information copied from DNA in chromosomes that is destined to be translated into proteins. In every cell there at maybe 15,000 different mRNAs produced at any given time. As they are only transient signals, mRNAs are rapidly degraded. The half life of an individual mRNA can be measured in minutes. Some may be longer lived. But they do not persist in the cell.
So this general principle has been used to make mRNA-based vaccines. Basically, a synthetic version of an important viral protein (here a modified version of the spike protein on the external coat of the virus) is made as mRNA code. Because mRNA is so fragile, the vaccine version is coated with various lipid polymers. These act to shield the mRNA and to help it move through the cell membrane. Once in the cell, the mRNA is read and a version of the coat protein is expressed. This protein can then be processed for recognition by the immune system, and an immune response made against the protein. If it works well, white blood cells called T cells become activated. These in turn can activate other important cells of the immune system that lead to antibody production and eventually different classes of memory cells. The antibodies produced bind to coat proteins found on new virus particles and block their entry into cells. The memory white blood cells persist for many years and can rapidly become activated by new virus. mRNA vaccines were originally designed to enhance natural immunity against cancer. Tons of resources were used to design this platform. For various reasons, the tumor vaccine approach has hit roadblocks, but the overall technology is now used for many veterinary vaccines, and now of course more recently vaccines in humans.
Does this answer your question?April 12, 2021 at 12:19 am #186229
If anyone is interested in how this stuff works, here is a good overview of the biology underlying how mRNA vaccines.March 30, 2021 at 2:59 am #185523March 30, 2021 at 2:48 am #185522
Well… in short, not all nuts grow on trees….December 30, 2020 at 1:07 am #180938
Charlatans and Wackjobs!
This is pure unadulterated BS! I shouldn’t have watched this crap while drinking my coffee this morning, it made me yuk a bunch of it out my nose….
Not a real pandemic? The 80+ million people who have contracted the virus, and the families of the almost 2 million who have died from it worldwide would beg to differ. Pick up a dictionary, look up the definition of “pandemic”…..
mRNA vaccines (mRNA in general) cannot, and will not “change” DNA. No No No Anyone who says it does is profoundly ignorant of the basic biology at work and the mountains of relevant peer reviewed literature, or are just true believers and regardless of the facts – just chose to ignore them.
mRNA vaccines are untried and untested?
In fact, mRNA vaccines have been used for many years in the field of cancer vaccination. There is a huge amount of data regarding their efficacy and application. The group in Germany behind the Pfizer vaccine has spent the last 20+ years developing this technology for cancer treatments. This is why the approach could be brought so quickly into play against Covid. It’s just the first time that that it has been used as a viral vaccine.
Antibodies and autoimmunity
The potential side effects of enhanced pro-viral antibodies during vaccination is well-recognized in the field of vaccination research, and represents one of the first things looked for during their development. To date, in the hundreds of thousands given the various vaccines worldwide, no negative antibody effects have been identified. Zero, Zippo, Nada, None………
It’s way too soon….
Was it rushed, well Ya……. it’s an emergency, regardless of what some nutjob in a video says. Think Covid is a made up problem? Why don’t you put your own ass on the line – go volunteer to work in a hospital, right now – many are at the breaking point, they certainly could use additional help, even if it is only to take coffee to the overworked and overwhelmed staff.
Are their side effects of vaccination? Yes. Some people experience flu-like symptoms, a few can have allergic symptoms, and a tiny tiny fraction may have more dramatic side effects. This is why for example in the US (but to my knowledge less so in other countries) they have established a fund to shield developers (think runaway jury awards).August 8, 2020 at 11:17 pm #173368
Молодцы вы, кучка бездумных марионеток ….July 10, 2020 at 8:24 am #171656
This is a complete load of BS, distortion and misquoting, hammered into place to fit into a complete looney tunes narrative.
HCQ acts by altering the pH of endosomes, cellular structures where peptides are loaded on to proteins called MHC class II molecules, that then go on to help regulate the immune response, and through this alter the inflammatory phase of Covid. As it happens, this structure is also important to the life cycle of plasmodium vivax – the malaria parasite. It is not in any way shape or form a cure for Covid 19. It MAY be able moderate course of the disease SOMETIMES. Do you have any idea how many physicians have died during this pandemic? Do you honestly think that they would allow themselves to die to support some Looney Tunes conspiracy? Do you honestly think that HCQ hasn’t been tried in every hospital with sick people in every possible combination. Sweet god in heaven – get a grip!July 1, 2020 at 6:56 am #171319
Ouch! Now that’s going to leave a mark…July 1, 2020 at 6:21 am #171317
What is America doing wrong?
This chart illustrates the spectacularly poor job that the U.S. has done in containing Covid-19 as compared to the European Union, a bigger more densely populated region of 27 independent countries that suffered an earlier outbreak. The EU has now largely opened up and is returning to some level of normality. So why the big difference? What has the EU done right? The EU took the advice of the WHO, enacted aggressive testing and tracing, used self quarantine, banned large gatherings and required the use of face masks in some settings. It’s really just not that complicated.